Dictating histone occupancy
نویسندگان
چکیده
منابع مشابه
Gene promoters dictate histone occupancy within genes.
Spt6 is a transcriptional elongation factor and histone chaperone that reassembles transcribed chromatin. Genome-wide H3 mapping showed that Spt6 preferentially maintains nucleosomes within the first 500 bases of genes and helps define nucleosome-depleted regions in 5' and 3' flanking sequences. In Spt6-depleted cells, H3 loss at 5' ends correlates with reduced pol II density suggesting enhance...
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ژورنال
عنوان ژورنال: Nature Structural & Molecular Biology
سال: 2013
ISSN: 1545-9993,1545-9985
DOI: 10.1038/nsmb.2694